Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
Jaroslav A Hubacek, Silvie Bloudícková, Romana Bohuslavová, Petr Táborský, Vladimír Polakovic, Magdaléna Sazamová, Eva Svítilová, Jicí Vlasák, Iva Sojková, Miroslav Ryba, Petr Knetl, Martin Ullrych, Radim Drahozal, Veronika Pavuková, Beata Pavlíková, Drahomíra Fischlová, Magdaléna Mokrejsová, Hana Chmelícková, Eva Pauchová, Pavel Vyskocil, Zuzana Nýdlová, Jaroslav Kopenec, Petr Fixa, Jan Hajný, Petr Bubenícek, Petr Syrovátka, Jana Zahálková, Stanislav Surel, Zdenek Hobzek, Ales Hrubý, Jana Suchanová, Svetlana Vanková, Jana Brabcová, Ondrej Viklický, MIA Group
DOI: 10.1515/CCLM.2007.141
Klíčová slova: Alleles, Arginine, Body Mass Index, Dialysis, Female, Genetic Variation, Ghrelin, Glutamine, Heterozygote, Humans, Cholesterol, Leucine, Male, Methionine, Renal Dialysis, Renal Insufficiency
Anotace: BACKGROUND: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications. BACKGROUND: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications. BACKGROUND: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications. BACKGROUND: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body's energy balance. We analyzed the association of ghrelin variants with body mass index (BMI), albumin as a marker of malnutrition and plasma lipids as risk factors for atherosclerosis in hemodialyzed patients, in whom malnutrition and accelerated atherosclerosis are common complications.
Citace: HUBACEK, Jaroslav A, Silvie BLOUDÍCKOVÁ, Romana BOHUSLAVOVÁ, et al. Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients. Clinical chemistry and laboratory medicine: CCLM / FESCC. 2007, 45(9), 1121-1123. ISSN 14346621. Dostupné z: doi:10.1515/CCLM.2007.141