Local electrogram delay recorded from left ventricular lead at implant predicts response to cardiac resynchronization therapy: retrospective study with 1 year follow up

Rostislav Polasek, Pavel Kucera, Pavel Nedbal, Tomas Roubicek, Tomas Belza, Jana Hanuliakova, David Horak, Dan Wichterle, Josef Kautzner

DOI: 10.1186/1471-2261-12-34

Klíčová slova: Adult, Aged, Aged, 80 and over, Biological Markers, Bundle-Branch Block, Cardiac Resynchronization Therapy, Cardiac Resynchronization Therapy Devices, Czech Republic, Electrophysiologic Techniques, Cardiac, Equipment Design, Female, Heart Block, Heart Failure, Humans, Chi-Square Distribution, Linear Models, Male, Middle Aged, Multivariate Analysis, Natriuretic Peptide, Brain, Peptide Fragments, Predictive Value of Tests, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Ventricular Function, Left, Ventricular Remodeling

Anotace: BACKGROUND: Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response. BACKGROUND: Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response. BACKGROUND: Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response. BACKGROUND: Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response.

Citace: POLASEK, Rostislav, Pavel KUCERA, Pavel NEDBAL, et al. Local electrogram delay recorded from left ventricular lead at implant predicts response to cardiac resynchronization therapy: retrospective study with 1 year follow up: retrospective study with 1 year follow up. BMC cardiovascular disorders. 2012, 12, 34. ISSN 14712261. Dostupné z: doi:10.1186/1471-2261-12-34

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