[Primary cilia of cells of cardiovascular apparatus]
J Dvořák, V Sitorová, D H Nikolov, J Mokrý, I Richter, S Filip, A Ryška, J Petera
Klíčová slova: Cilia, Endothelial Cells, Humans, Muscle, Smooth, Vascular, Myocytes, Cardiac
Anotace: The primary cilium is a mechanosensory, solitary, non-motile microtubule-based structure that in the quiescent phase of the cell cycle projects from the surface of the majority of human cells, including embryonal, stem and mesenchymal cells, fibroblasts, myoblasts, cardiomyocytes, vascular smooth muscle and endothelial cells. Primary cilia are in increased frequency also present on the surface of endothelial cells in atherosclerotic predilection sites, lipoid streaks and dots and atheromatous plaques. The primary cilium is formed from the mother centriole. Primary cilia are currently studied in mechanobiology of cardiovascular apparatus and their role in cell migration, cell cycle control and atherogenesis. The aim of this paper is to provide a review of the current knowledge on the primary cilia of cells of cardiovascular apparatus.
Citace: DVOŘÁK, J, V SITOROVÁ, D H NIKOLOV, J MOKRÝ, I RICHTER, S FILIP, A RYŠKA a J PETERA. [Primary cilia of cells of cardiovascular apparatus]. Vnitr̆ní lékar̆ství. 2012, 58(12), 938-942. ISSN 0042773x.